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Does depth of squat-stand maneuver affect estimates of dynamic cerebral autoregulation?

ABSTRACT: Repeated squat-stand maneuvers (SSM) are an effective way of measuring dynamic cerebral autoregulation (dCA), but the depth of SSM required to improve dCA estimations has never been studied. We compared beat-to-beat cerebral hemodynamic parameters between maximal depth SSM (SSMD ) and a shallower alternative (SSMS ) in two age groups (younger [20-34 years] vs. older [50-71 years]) at a frequency of 0.05 Hz. Cerebral blood flow velocity, continuous blood pressure (BP) and end-tidal CO2 (EtCO2 ) were measured using transcranial Doppler ultrasound, the Finometer device, and capnography, respectively. Coherence (at 0.05 Hz) was significantly higher in both SSM recordings compared to spontaneous BP oscillations at baseline standing (BS ). Median (IQR) autoregulation index (ARI) was reduced during SSMD (4.46 [4.03-5.22], p < .01) compared to SSMS (5.96 [5.40-6.69]) and BS (6.03 [5.20-6.49], p < .01) with similar relative differences also observed for phase (at 0.05 Hz). End-tidal CO2 was increased in SSMD (38.3 ± 3.7 mmHg, p < .01) compared to both SSMS (36.6 ± 3.6 mmHg) and BS (35.5 ± 3.2 mmHg). The older group demonstrated significantly lower ARI and phase estimates during SSM and found SSMS more effortful than SSMD . In conclusion, both SSMD and SSMS are effective at estimating dCA, and dCA appears to be less efficient during maximal depth SSM compared to baseline rest or a shallower alternative.

SUBMITTER: Batterham AP

PROVIDER: S-EPMC7435029 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Does depth of squat-stand maneuver affect estimates of dynamic cerebral autoregulation?

Batterham Angus P AP Panerai Ronney B RB Robinson Thompson G TG Haunton Victoria J VJ

Physiological reports 20200801 16

Repeated squat-stand maneuvers (SSM) are an effective way of measuring dynamic cerebral autoregulation (dCA), but the depth of SSM required to improve dCA estimations has never been studied. We compared beat-to-beat cerebral hemodynamic parameters between maximal depth SSM (SSM<sub>D</sub> ) and a shallower alternative (SSM<sub>S</sub> ) in two age groups (younger [20-34 years] vs. older [50-71 years]) at a frequency of 0.05 Hz. Cerebral blood flow velocity, continuous blood pressure (BP) and en ...[more]

PMID: 32812372

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Project description:Breath-hold divers (BHD) experience repeated bouts of severe hypoxia and hypercapnia with large increases in blood pressure. However, the impact of long-term breath-hold diving on cerebrovascular control remains poorly understood. The ability of cerebral blood vessels to respond rapidly to changes in blood pressure represents the property of dynamic autoregulation. The current investigation tested the hypothesis that breath-hold diving impairs dynamic autoregulation to a transient hypotensive stimulus. Seventeen BHD (3 women, 11?±?9 yr of diving) and 15 healthy controls (2 women) completed two or three repeated sit-to-stand trials during spontaneous breathing and poikilocapnic conditions. Heart rate (HR), finger arterial blood pressure (BP), and cerebral blood flow velocity (BFV) from the right middle cerebral artery were measured continuously with three-lead electrocardiography, finger photoplethysmography, and transcranial Doppler ultrasonography, respectively. End-tidal carbon dioxide partial pressure was measured with a gas analyzer. Offline, an index of cerebrovascular resistance (CVRi) was calculated as the quotient of mean BP and BFV. The rate of the drop in CVRi relative to the change in BP provided the rate of regulation [RoR; (?CVRi/?T)/?BP]. The BHD demonstrated slower RoR than controls (P ? 0.001, d?=?1.4). Underlying the reduced RoR in BHD was a longer time to reach nadir CVRi compared with controls (P = 0.004, d?=?1.1). In concert with the longer CVRi response, the time to reach peak BFV following standing was longer in BHD than controls (P = 0.01, d?=?0.9). The data suggest impaired dynamic autoregulatory mechanisms to hypotension in BHD. NEW & NOTEWORTHY Impairments in dynamic cerebral autoregulation to hypotension are associated with breath-hold diving. Although weakened autoregulation was observed acutely in this group during apneic stress, we are the first to report on chronic adaptations in cerebral autoregulation. Impaired vasomotor responses underlie the reduced rate of regulation, wherein breath-hold divers demonstrate a prolonged dilatory response to transient hypotension. The slower cerebral vasodilation produces a longer perturbation in cerebral blood flow velocity, increasing the risk of cerebral ischemia.

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Does depth of squat-stand maneuver affect estimates of dynamic cerebral autoregulation?

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Does depth of squat-stand maneuver affect estimates of dynamic cerebral autoregulation?

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