Ontology highlight
ABSTRACT:
SUBMITTER: Neumann H
PROVIDER: S-EPMC7435766 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20200728 15
A flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (<b>9</b>) which enabled the efficient sequential palladium-catalyzed Heck coupling of aryl bromides with ethylene and hydroxycarbonylation of the resulting styrenes to 2-aryl propionic acids. This cascade transformation leads with h ...[more]