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Negative Correlation Between Functional Connectivity and Small-Worldness in the Alpha Frequency Band of a Healthy Brain.

ABSTRACT: The aim of the study was to analyze the relationship between resting state electroencephalographic (EEG) alpha functional connectivity (FC) and small-world organization. For that purpose, Pearson correlation was calculated between FC and small-worldness (SW). Three undirected FC measures were used: magnitude-squared coherence (MSC), imaginary part of coherency (ICOH), and synchronization likelihood (SL). As a result, statistically significant negative correlation occurred between FC and SW for all three FC measures. Small-worldness of MSC and SL were mostly above 1, but lower than 1 for ICOH, suggesting that functional EEG networks did not have small-world properties. Based on the results of the current study, we suggest that decreased alpha small-world organization is compensated with increased connectivity of alpha oscillations in a healthy brain.

SUBMITTER: Paeske L

PROVIDER: S-EPMC7437013 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Negative Correlation Between Functional Connectivity and Small-Worldness in the Alpha Frequency Band of a Healthy Brain.

Päeske Laura L Hinrikus Hiie H Lass Jaanus J Raik Jaan J Bachmann Maie M

Frontiers in physiology 20200812

The aim of the study was to analyze the relationship between resting state electroencephalographic (EEG) alpha functional connectivity (FC) and small-world organization. For that purpose, Pearson correlation was calculated between FC and small-worldness (SW). Three undirected FC measures were used: magnitude-squared coherence (MSC), imaginary part of coherency (ICOH), and synchronization likelihood (SL). As a result, statistically significant negative correlation occurred between FC and SW for a ...[more]

PMID: 32903521

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Project description:Numerous efforts have been devoted to revealing neurophysiological mechanisms of mental fatigue, aiming to find an effective way to reduce the undesirable fatigue-related outcomes. Until recently, mental fatigue is thought to be related to functional dysconnectivity among brain regions. However, the topological representation of brain functional connectivity altered by mental fatigue is only beginning to be revealed. In the current study, we applied a graph theoretical approach to analyse such topological alterations in the lower alpha band (8~10 Hz) of EEG data from 20 subjects undergoing a two-session experiment, in which one session includes four successive blocks with visual oddball tasks (session 1) whereas a mid-task break was introduced in the middle of four task blocks in the other session (session 2). Phase lag index (PLI) was then employed to measure functional connectivity strengths for all pairs of EEG channels. Behavior and connectivity maps were compared between the first and last task blocks in both sessions. Inverse efficiency scores (IES = reaction time/response accuracy) were significantly increased in the last task block, showing a clear effect of time-on-task in participants. Furthermore, a significant block-by-session interaction was revealed in the IES, suggesting the effectiveness of the mid-task break on maintaining task performance. More importantly, a significant session-independent deficit of global integration and an increase of local segregation were found in the last task block across both sessions, providing further support for the presence of a reshaped topology in functional brain connectivity networks under fatigue state. Moreover, a significant block-by-session interaction was revealed in the characteristic path length, small-worldness, and global efficiency, attributing to the significantly disrupted network topology in session 1 in comparison of the maintained network structure in session 2. Specifically, we found increased nodal betweenness centrality in several channels resided in frontal regions in session 1, resembling the observations of more segregated global architecture under fatigue state. Taken together, our findings provide insights into the substrates of brain functional dysconnectivity patterns for mental fatigue and reiterate the effectiveness of the mid-task break on maintaining brain network efficiency.

Dataset Information

Negative Correlation Between Functional Connectivity and Small-Worldness in the Alpha Frequency Band of a Healthy Brain.

Publications

Negative Correlation Between Functional Connectivity and Small-Worldness in the Alpha Frequency Band of a Healthy Brain.

Similar Datasets

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