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TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?

ABSTRACT: TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.

SUBMITTER: Stopsack KH

PROVIDER: S-EPMC7437472 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?

Stopsack Konrad H KH Mucci Lorelei A LA Antonarakis Emmanuel S ES Nelson Peter S PS Kantoff Philip W PW

Cancer discovery 20200410 6

TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections. ...[more]

PMID: 32276929

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