Moderate alcohol use is associated with decreased brain volume in early middle age in both sexes.

ABSTRACT: The aim was to examine cross-sectional association between moderate alcohol consumption and total brain volume in a cohort of participants in early middle-age, unconfounded by age-related neuronal change. 353 participants aged 39 to 45 years reported on their alcohol consumption using the AUDIT-C measure. Participants with alcohol abuse were excluded. Brain MRI was analyzed using a fully automated method. Brain volumes were adjusted by intracranial volume expressed as adjusted total brain volume (aTBV). AUDIT-C mean of 3.92 (SD 2.04) indicated moderate consumption. In a linear regression model, alcohol consumption was associated with smaller aTBV (B?=?- 0.258, p?

SUBMITTER: Immonen S 

PROVIDER: S-EPMC7438498 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature