Ontology highlight
ABSTRACT:
SUBMITTER: Lee JS
PROVIDER: S-EPMC7438788 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Lee Ji-Sook JS Lee Na Rae NR Kashif Ayesha A Yang Seung-Ju SJ Nam A Reum AR Song Ik-Chan IC Gong Soo-Jung SJ Hong Min Hwa MH Kim Geunyeong G Seok Pu Reum PR Lee Myung-Shin MS Sung Kee-Hyung KH Kim In Sik IS
Frontiers in immunology 20200806
S100A8 and S100A9 function as essential factors in inflammation and also exert antitumor or tumorigenic activity depending on the type of cancer. Chronic eosinophilic leukemia (CEL) is a rare hematological malignancy having elevated levels of eosinophils and characterized by the presence of the <i>FIP1L1-PDGFRA</i> fusion gene. In this study, we examined the pro-apoptotic mechanisms of S100A8 and S100A9 in FIP1L1-PDGFRα+ eosinophilic cells and hypereosinophilic patient cells. S100A8 and S100A9 i ...[more]