Dataset Information

Integrative Analysis Revealing Human Heart-Specific Genes and Consolidating Heart-Related Phenotypes.

ABSTRACT: Elucidating expression patterns of heart-specific genes is crucial for understanding developmental, physiological, and pathological processes of the heart. The aim of the present study is to identify functionally and pathologically important heart-specific genes by performing the Ingenuity Pathway Analysis (IPA). Through a median-based analysis of tissue-specific gene expression based on the Genotype-Tissue Expression (GTEx) data, we identified 56 genes with heart-specific or elevated expressions in the heart (heart-specific/enhanced), among which three common heart-specific/enhanced genes and four atrial appendage-specific/enhanced genes were unreported regarding the heart. Differential expression analysis further revealed 225 differentially expressed genes (DEGs) between atrial appendage and left ventricle. Our integrative analyses of those heart-specific/enhanced genes and DEGs with IPA revealed enriched heart-related traits and diseases, consolidating evidence of relationships between these genes and heart function. Our reports on comprehensive identification of heart-specific/enhanced genes and DEGs and their relation to pathways associated with heart-related traits and diseases provided molecular insights into essential regulators of cardiac physiology and pathophysiology and potential new therapeutic targets for heart diseases.

SUBMITTER: Ahn J

PROVIDER: S-EPMC7438927 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Integrative Analysis Revealing Human Heart-Specific Genes and Consolidating Heart-Related Phenotypes.

Ahn Jinsoo J Wu Huiguang H Lee Kichoon K

Frontiers in genetics 20200730

Elucidating expression patterns of heart-specific genes is crucial for understanding developmental, physiological, and pathological processes of the heart. The aim of the present study is to identify functionally and pathologically important heart-specific genes by performing the Ingenuity Pathway Analysis (IPA). Through a median-based analysis of tissue-specific gene expression based on the Genotype-Tissue Expression (GTEx) data, we identified 56 genes with heart-specific or elevated expression ...[more]

PMID: 32903789

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Dataset Information

Integrative Analysis Revealing Human Heart-Specific Genes and Consolidating Heart-Related Phenotypes.

Publications

Integrative Analysis Revealing Human Heart-Specific Genes and Consolidating Heart-Related Phenotypes.

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