Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC7439098 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Xu XiXi X Roseblade Ariane A Rawling Tristan T Ung Alison T AT
RSC medicinal chemistry 20191218 1
A library of novel tricyclic amides has been synthesised <i>via</i> the Ritter reaction from β-caryophyllene <b>1</b> and its monoepoxy derivative <b>4</b>. The compounds were assessed for antiproliferative activities against the aggressive MDA-MB-231 breast cancer cell line. Of the synthesised compounds, eight were active. <b>3c</b> and <b>6b</b> were the most potent and inhibited proliferation with IC<sub>50</sub> of 9.7 and 8.2 μM, respectively. Mechanistic studies revealed differences in the ...[more]