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Detection of response to tumor microenvironment-targeted cellular immunotherapy using nano-radiomics.

ABSTRACT: Immunotherapies, including cell-based therapies, targeting the tumor microenvironment (TME) result in variable and delayed responses. Thus, it has been difficult to gauge the efficacy of TME-directed therapies early after administration. We investigated a nano-radiomics approach (quantitative analysis of nanoparticle contrast-enhanced three-dimensional images) for detection of tumor response to cellular immunotherapy directed against myeloid-derived suppressor cells (MDSCs), a key component of TME. Animals bearing human MDSC-containing solid tumor xenografts received treatment with MDSC-targeting human natural killer (NK) cells and underwent nanoparticle contrast-enhanced computed tomography (CT) imaging. Whereas conventional CT-derived tumor metrics were unable to differentiate NK cell immunotherapy tumors from untreated tumors, nano-radiomics revealed texture-based features capable of differentiating treatment groups. Our study shows that TME-directed cellular immunotherapy causes subtle changes not effectively gauged by conventional imaging metrics but revealed by nano-radiomics. Our work provides a method for noninvasive assessment of TME-directed immunotherapy potentially applicable to numerous solid tumors.

SUBMITTER: Devkota L

PROVIDER: S-EPMC7439308 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Detection of response to tumor microenvironment-targeted cellular immunotherapy using nano-radiomics.

Devkota Laxman L Starosolski Zbigniew Z Rivas Charlotte H CH Stupin Igor I Annapragada Ananth A Ghaghada Ketan B KB Parihar Robin R

Science advances 20200710 28

Immunotherapies, including cell-based therapies, targeting the tumor microenvironment (TME) result in variable and delayed responses. Thus, it has been difficult to gauge the efficacy of TME-directed therapies early after administration. We investigated a nano-radiomics approach (quantitative analysis of nanoparticle contrast-enhanced three-dimensional images) for detection of tumor response to cellular immunotherapy directed against myeloid-derived suppressor cells (MDSCs), a key component of T ...[more]

PMID: 32832602

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Dataset Information

Detection of response to tumor microenvironment-targeted cellular immunotherapy using nano-radiomics.

Publications

Detection of response to tumor microenvironment-targeted cellular immunotherapy using nano-radiomics.

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