Ontology highlight
ABSTRACT:
SUBMITTER: Rajapakse VN
PROVIDER: S-EPMC7439317 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Rajapakse Vinodh N VN Herrada Sylvia S Lavi Orit O
Science advances 20200527 22
Although tumor invasiveness is known to drive glioblastoma (GBM) recurrence, current approaches to treatment assume a fairly simple GBM phenotype transition map. We provide new analyses to estimate the likelihood of reaching or remaining in a phenotype under dynamic, physiologically likely perturbations of stimuli ("phenotype stability"). We show that higher stability values of the motile phenotype (Go) are associated with reduced patient survival. Moreover, induced motile states are capable of ...[more]