Ontology highlight
ABSTRACT:
SUBMITTER: Ren Y
PROVIDER: S-EPMC7439498 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Science advances 20200717 29
Calcium homeostasis modulator 1 (CALHM1) is a voltage-gated ATP release channel that plays an important role in neural gustatory signaling and the pathogenesis of Alzheimer's disease. Here, we present a cryo-electron microscopy structure of full-length Ca<sup>2+</sup>-free CALHM1 from Danio rerio at an overall resolution of 3.1 Å. Our structure reveals an octameric architecture with a wide pore diameter of ~20 Å, presumably representing the active conformation. The overall structure is substanti ...[more]