Ontology highlight
ABSTRACT:
SUBMITTER: Sannerud R
PROVIDER: S-EPMC7439524 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Sannerud Ragna R Esselens Cary C Ejsmont Paulina P Mattera Rafael R Rochin Leila L Tharkeshwar Arun Kumar AK De Baets Greet G De Wever Veerle V Habets Roger R Baert Veerle V Vermeire Wendy W Michiels Christine C Groot Arjan J AJ Wouters Rosanne R Dillen Katleen K Vints Katlijn K Baatsen Pieter P Munck Sebastian S Derua Rita R Waelkens Etienne E Basi Guriqbal S GS Mercken Mark M Vooijs Marc M Bollen Mathieu M Schymkowitz Joost J Rousseau Frederic F Bonifacino Juan S JS Van Niel Guillaume G De Strooper Bart B Annaert Wim W
Cell 20160609 1
γ-Secretases are a family of intramembrane-cleaving proteases involved in various signaling pathways and diseases, including Alzheimer's disease (AD). Cells co-express differing γ-secretase complexes, including two homologous presenilins (PSENs). We examined the significance of this heterogeneity and identified a unique motif in PSEN2 that directs this γ-secretase to late endosomes/lysosomes via a phosphorylation-dependent interaction with the AP-1 adaptor complex. Accordingly, PSEN2 selectively ...[more]