Ontology highlight
ABSTRACT:
SUBMITTER: Ma F
PROVIDER: S-EPMC7439549 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Ma Feihe F Yang Liu L Sun Zhuorui Z Chen Jinjin J Rui Xuehui X Glass Zachary Z Xu Qiaobing Q
Science advances 20200724 30
Safe and efficient delivery of blood-brain barrier (BBB)-impermeable cargos into the brain through intravenous injection remains a challenge. Here, we developed a previously unknown class of neurotransmitter-derived lipidoids (NT-lipidoids) as simple and effective carriers for enhanced brain delivery of several BBB-impermeable cargos. Doping the NT-lipidoids into BBB-impermeable lipid nanoparticles (LNPs) gave the LNPs the ability to cross the BBB. Using this brain delivery platform, we successf ...[more]