Dataset Information

Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies.

ABSTRACT: BACKGROUND:The incidence of thyroid carcinoma is increasing all over the world. Some studies have suggested that the change of adipokines expression can induce thyroid carcinoma. However, other studies have come to the opposite conclusion. Therefore, we studied the relationship between adipokines and thyroid carcinoma. METHODS:Databases-PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries were searched. A meta-analysis was then performed through a fixed or random-effects model to calculate I values for heterogeneity analysis. RESULTS:Twenty-nine articles were finally included for analysis. The level of serum tumor necrosis factor-alpha (TNF-?) [standardized mean difference (SMD) =1.31, 95% confidence interval (95% CI): 0.35 to 2.28, I2?=?98%, P?=?0.008] and the ratio of TNF-? immunoreactivity in tissues [odds ratios (OR) =6.36, 95% CI: 1.92 to 21.05, I2?=?66%, P?=?0.002] in thyroid carcinoma are significantly higher than those in control. The serum interleukin-6 (IL-6) in patients with thyroid carcinoma is higher than that in control (SMD?=?1.04, 95% CI: 0.40 to 1.67, I2?=?96%, P?=?0.001). There is no significant difference of the ratio of IL-6 immunoreactivity in tissues between carcinoma and control (OR?=?1.23, 95% CI: 0.62 to 2.43, I2?=?86%, P?=?0.55). The ratio of leptin immunoreactivity in tissues is significantly associated with the risk of thyroid carcinoma (OR?=?12.21, 95% CI: 3.36 to 44.40, I2?=?85%, P?

SUBMITTER: Zhao J

PROVIDER: S-EPMC7441682 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies.

Zhao Junyu J Wen Jing J Wang Shengnan S Yao Jinming J Liao Lin L Dong Jianjun J

BMC cancer 20200820 1

<h4>Background</h4>The incidence of thyroid carcinoma is increasing all over the world. Some studies have suggested that the change of adipokines expression can induce thyroid carcinoma. However, other studies have come to the opposite conclusion. Therefore, we studied the relationship between adipokines and thyroid carcinoma.<h4>Methods</h4>Databases-PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries were searched. A meta-analysis was then performed through a fixed ...[more]

PMID: 32819324

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Project description:BackgroundPrevious studies investigating the association between X-ray repair cross-complementing group 1 (XRCC1) polymorphisms and thyroid cancer risk have yielded inconsistent results. This meta-analysis was performed to derive a more precise estimation of the relationship between three XRCC1 polymorphisms and thyroid cancer risk.Methods/principal findingsPubMed and EMBASE database were systematically searched to identify relevant studies. 10 publications were selected for this meta-analysis, including 11 studies for Arg399Gln polymorphism (1726 cases and 3774 controls), 7 studies for Arg194Trp polymorphism (1037 cases and 2487 controls) and 8 studies for Arg280His polymorphism (1432 cases and 3356 controls). The results in total population did not show any significant association between these three polymorphisms and the risk of DTC for all genetic models. However, when stratified by ethnicity, the results showed that Arg280His polymorphism was associated with an increased risk of DTC among Caucasians (Arg/His vs. Arg/Arg: OR = 1.45, 95% CI = 1.09-1.93; dominant model: OR = 1.43, 95% CI = 1.08-1.89; additive model: OR = 1.38, 95% CI = 1.05-1.80), whereas individuals carrying Arg/His genotype have a significantly reduced risk of DTC among Asians (Arg/His vs. Arg/Arg: OR = 0.71, 95% CI = 0.51-0.98). We also detected that 399Gln variant allele carriers might presented an overall decreased risk of DTC in mixed population. Furthermore, subgroup analyses by histological subtype revealed that Arg194Trp polymorphism was significantly associated with reduced risk for papillary thyroid carcinoma (PTC) (dominant model: OR = 0.71, 95% CI = 0.50-0.99).ConclusionsThis meta-analysis suggests that Arg280His polymorphism might contribute to the susceptibility of DTC among Caucasians, whereas it might provide protective effects in Asians against the risk of DTC. Additionally, our results support the protective role of Arg194Trp polymorphism in developing PTC, and show evidence of an association between Arg399Gln polymorphism and decreased risk of DTC in mixed population.

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Dataset Information

Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies.

Publications

Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies.

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