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On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity.

ABSTRACT: We propose here that one of the potential mechanisms for the relapse of the COVID-19 infection could be a cellular transport pathway associated with the release of the SARS-CoV-2-loaded exosomes and other extracellular vesicles. It is possible that this "Trojan horse" strategy represents possible explanation for the re-appearance of the viral RNA in the recovered COVID-19 patients 7-14?day post discharge, suggesting that viral material was hidden within such exosomes or extracellular vesicles during this "silence" time period and then started to re-spread again. Communicated by Ramaswamy H. Sarma.

SUBMITTER: Elrashdy F

PROVIDER: S-EPMC7441802 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity.

Elrashdy Fatma F Aljaddawi Abdullah A AA Redwan Elrashdy M EM Uversky Vladimir N VN

Journal of biomolecular structure & dynamics 20200709 15

We propose here that one of the potential mechanisms for the relapse of the COVID-19 infection could be a cellular transport pathway associated with the release of the SARS-CoV-2-loaded exosomes and other extracellular vesicles. It is possible that this "Trojan horse" strategy represents possible explanation for the re-appearance of the viral RNA in the recovered COVID-19 patients 7-14 day post discharge, suggesting that viral material was hidden within such exosomes or extracellular vesicles du ...[more]

PMID: 32643586

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