Ontology highlight
ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC7442216 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Liu Qingbo Q Cheng Yung-Yi YY Li Wei W Huang Li L Asada Yoshihisa Y Hsieh Min-Tsang MT Morris-Natschke Susan L SL Chen Chin-Ho CH Koike Kazuo K Lee Kuo-Hsiung KH
Journal of medicinal chemistry 20190725 15
Currently, due to the HIV latency mechanism, the search continues for effective drugs to combat this issue and provide a cure for AIDS. Gnidimacrin activates latent HIV-1 replication and inhibits HIV-1 infection at picomolar concentrations. This natural diterpene was able to markedly reduce the latent HIV-1 DNA level and the frequency of latently infected cells. Therefore, gnidimacrin is an excellent lead compound, and its anti-HIV potential merits further investigation. Twenty-nine modified gni ...[more]