Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC7442600 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Liu Chang C Somasundaram Ashwin A Manne Sasikanth S Gocher Angela M AM Szymczak-Workman Andrea L AL Vignali Kate M KM Scott Ellen N EN Normolle Daniel P DP John Wherry E E Lipson Evan J EJ Ferris Robert L RL Bruno Tullia C TC Workman Creg J CJ Vignali Dario A A DAA
Nature immunology 20200713 9
Robust CD8<sup>+</sup> T cell memory is essential for long-term protective immunity but is often compromised in cancer, where T cell exhaustion leads to loss of memory precursors. Immunotherapy via checkpoint blockade may not effectively reverse this defect, potentially underlying disease relapse. Here we report that mice with a CD8<sup>+</sup> T cell-restricted neuropilin-1 (NRP1) deletion exhibited substantially enhanced protection from tumor rechallenge and sensitivity to anti-PD1 immunothera ...[more]