Ontology highlight
ABSTRACT:
SUBMITTER: Leclerc M
PROVIDER: S-EPMC6659631 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nature communications 20190726 1
Neuropilin-1 (Nrp-1) is a marker for murine CD4<sup>+</sup>FoxP3<sup>+</sup> regulatory T (Treg) cells, a subset of human CD4<sup>+</sup> Treg cells, and a population of CD8<sup>+</sup> T cells infiltrating certain solid tumours. However, whether Nrp-1 regulates tumour-specific CD8 T-cell responses is still unclear. Here we show that Nrp-1 defines a subset of CD8<sup>+</sup> T cells displaying PD-1<sup>hi</sup> status and infiltrating human lung cancer. Interaction of Nrp-1 with its ligand semap ...[more]