Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis.
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ABSTRACT:
SUBMITTER: Meguro A
PROVIDER: S-EPMC7442816 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis.
Meguro Akira A Ishihara Mami M Petrek Martin M Yamamoto Ken K Takeuchi Masaki M Mrazek Frantisek F Kolek Vitezslav V Benicka Alzbeta A Yamane Takahiro T Shibuya Etsuko E Yoshino Atsushi A Isomoto Akiko A Ota Masao M Yatsu Keisuke K Shijubo Noriharu N Nagai Sonoko S Yamaguchi Etsuro E Yamaguchi Tetsuo T Namba Kenichi K Kaburaki Toshikatsu T Takase Hiroshi H Morimoto Shin-Ichiro SI Hori Junko J Kono Keiko K Goto Hiroshi H Suda Takafumi T Ikushima Soichiro S Ando Yasutaka Y Takenaka Shinobu S Takeuchi Masaru M Yuasa Takenosuke T Sugisaki Katsunori K Ohguro Nobuyuki N Hiraoka Miki M Kitaichi Nobuyoshi N Sugiyama Yukihiko Y Horita Nobuyuki N Asukata Yuri Y Kawagoe Tatsukata T Kimura Ikuko I Ishido Mizuho M Inoko Hidetoshi H Mochizuki Manabu M Ohno Shigeaki S Bahram Seiamak S Remmers Elaine F EF Kastner Daniel L DL Mizuki Nobuhisa N
Communications biology 20200821 1
Sarcoidosis is a genetically complex systemic inflammatory disease that affects multiple organs. We present a GWAS of a Japanese cohort (700 sarcoidosis cases and 886 controls) with replication in independent samples from Japan (931 cases and 1,042 controls) and the Czech Republic (265 cases and 264 controls). We identified three loci outside the HLA complex, CCL24, STYXL1-SRRM3, and C1orf141-IL23R, which showed genome-wide significant associations (P < 5.0 × 10<sup>-8</sup>) with sarcoidosis; C ...[more]
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