Ontology highlight
ABSTRACT:
SUBMITTER: Smith HW
PROVIDER: S-EPMC7443881 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20200729 33
Lung cancer causes more deaths annually than any other malignancy. A subset of non-small cell lung cancer (NSCLC) is driven by amplification and overexpression or activating mutation of the receptor tyrosine kinase (RTK) <i>ERBB2</i> In some contexts, notably breast cancer, alternative splicing of <i>ERBB2</i> causes skipping of exon 16, leading to the expression of an oncogenic ERBB2 isoform (ERBB2ΔEx16) that forms constitutively active homodimers. However, the broader implications of <i>ERBB2< ...[more]