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SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19.

ABSTRACT: SARS-CoV-2 antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike IgG titers compared to those with severe coronavirus disease 2019 (COVID-19), likely reflecting a longer time since onset of infection in MIS-C patients.

SUBMITTER: Anderson EM

PROVIDER: S-EPMC7444298 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19.

Anderson Elizabeth M EM Diorio Caroline C Goodwin Eileen C EC McNerney Kevin O KO Weirick Madison E ME Gouma Sigrid S Bolton Marcus J MJ Arevalo Claudia P CP Chase Julie J Hicks Philip P Manzoni Tomaz B TB Baxter Amy E AE Andrea Kurt P KP Burudpakdee Chakkapong C Lee Jessica H JH Vella Laura A LA Henrickson Sarah E SE Harris Rebecca M RM Wherry E John EJ Bates Paul P Bassiri Hamid H Behrens Edward M EM Teachey David T DT Hensley Scott E SE

medRxiv : the preprint server for health sciences 20200818

SARS-CoV-2 antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike IgG titers compared to those with severe coronavirus disease 2019 (COVID-19), likely reflecting a longer time since onset of infection in MIS-C patients. ...[more]

PMID: 32839782

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