Ontology highlight
ABSTRACT:
SUBMITTER: Toledo DM
PROVIDER: S-EPMC7444604 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Current rheumatology reports 20190523 7
<h4>Purpose of review</h4>Macrophages play key roles in tissue homeostasis and immune surveillance, mobilizing immune activation in response to microbial invasion and promoting wound healing to repair damaged tissue. However, failure to resolve macrophage activation can lead to chronic inflammation and fibrosis, and ultimately to pathology. Activated macrophages have been implicated in the pathogenesis of systemic sclerosis (SSc), although the triggers that induce immune activation in SSc and th ...[more]