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J-shaped association between fasting blood glucose levels and COVID-19 severity in patients without diabetes.


ABSTRACT:

Aims

Coronavirus disease 2019 (COVID-19) has become a recognized worldwide pandemic. Researchers now know that mortality from COVID-19 can be reduced through early prevention measures. This retrospective, multi-centered study of 293 COVID-19 patients without diabetes explores the association between fasting blood glucose (FBG) levels and the risk of COVID-19 disease progression, with the goal of providing clinical evidence for glycemic targets in patients.

Methods

The multivariate stepwise binary logistic regression analysis was used to test the dose-response effects of FBG levels on the risk of severe and critical condition in COVID-19 patients.

Results

FBG levels were plotted in quintiles with set at <4.74, 4.74-5.21, 5.21-5.78, 5.78-7.05, and ≧7.05 mmol/L. The constituent ratio of severe or critical cases in each FBG quintile was 20.7%, 1.7%, 13.8%, 27.1%, and 67.2%, respectively (P < 0.0001). When the second quintile was used as the reference, the adjusted odds ratios (AORs) (95%CI) for the risk of severe/critical condition in COVID-19 was 25.33 (2.77, 231.64), 1.00 (Reference), 3.13 (0.33, 29.67), 10.59 (1.23, 91.24), 38.93 (4.36, 347.48) per FBG quintile respectively (P < 0.001).

Conclusions

We provide evidence of J-shaped associations between FBG and risk of severe and critical condition in non-diabetes patients with COVID-19, with nadir at 4.74-5.78 mmol/L.

SUBMITTER: Zhu B 

PROVIDER: S-EPMC7445136 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

J-shaped association between fasting blood glucose levels and COVID-19 severity in patients without diabetes.

Zhu Bing B   Jin Shengwei S   Wu Lianpeng L   Hu Chenchan C   Wang Zhen Z   Bu Le L   Sun Hang H   Wang Xingchun X   Qu Shen S   Chen Dong D  

Diabetes research and clinical practice 20200825


<h4>Aims</h4>Coronavirus disease 2019 (COVID-19) has become a recognized worldwide pandemic. Researchers now know that mortality from COVID-19 can be reduced through early prevention measures. This retrospective, multi-centered study of 293 COVID-19 patients without diabetes explores the association between fasting blood glucose (FBG) levels and the risk of COVID-19 disease progression, with the goal of providing clinical evidence for glycemic targets in patients.<h4>Methods</h4>The multivariate  ...[more]

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