Chromatin remodelling comes into focus.
Ontology highlight
ABSTRACT:
SUBMITTER: Sundaramoorthy R
PROVIDER: S-EPMC7445562 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Chromatin remodelling comes into focus.
Sundaramoorthy Ramasubramian R Owen-Hughes Tom T
F1000Research 20200820
ATP-dependent chromatin remodelling enzymes are molecular machines that act to reconfigure the structure of nucleosomes. Until recently, little was known about the structure of these enzymes. Recent progress has revealed that their interaction with chromatin is dominated by ATPase domains that contact DNA at favoured locations on the nucleosome surface. Contacts with histones are limited but play important roles in modulating activity. The ATPase domains do not act in isolation but are flanked b ...[more]
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