Ontology highlight
ABSTRACT:
SUBMITTER: Mirauta BA
PROVIDER: S-EPMC7447446 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Mirauta Bogdan Andrei BA Seaton Daniel D DD Bensaddek Dalila D Brenes Alejandro A Bonder Marc Jan MJ Kilpinen Helena H Stegle Oliver O Lamond Angus I AI
eLife 20200810
Human disease phenotypes are driven primarily by alterations in protein expression and/or function. To date, relatively little is known about the variability of the human proteome in populations and how this relates to variability in mRNA expression and to disease loci. Here, we present the first comprehensive proteomic analysis of human induced pluripotent stem cells (iPSC), a key cell type for disease modelling, analysing 202 iPSC lines derived from 151 donors, with integrated transcriptome an ...[more]