Ontology highlight
ABSTRACT:
SUBMITTER: Jager E
PROVIDER: S-EPMC7447633 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Jäger Elisabeth E Murthy Supriya S Schmidt Caroline C Hahn Magdalena M Strobel Sarah S Peters Anna A Stäubert Claudia C Sungur Pelin P Venus Tom T Geisler Mandy M Radusheva Veselina V Raps Stefanie S Rothe Kathrin K Scholz Roger R Jung Sebastian S Wagner Sylke S Pierer Matthias M Seifert Olga O Chang Wenhan W Estrela-Lopis Irina I Raulien Nora N Krohn Knut K Sträter Norbert N Hoeppener Stephanie S Schöneberg Torsten T Rossol Manuela M Wagner Ulf U
Nature communications 20200825 1
Increased extracellular Ca<sup>2+</sup> concentrations ([Ca<sup>2+</sup>]<sub>ex</sub>) trigger activation of the NLRP3 inflammasome in monocytes through calcium-sensing receptor (CaSR). To prevent extraosseous calcification in vivo, the serum protein fetuin-A stabilizes calcium and phosphate into 70-100 nm-sized colloidal calciprotein particles (CPPs). Here we show that monocytes engulf CPPs via macropinocytosis, and this process is strictly dependent on CaSR signaling triggered by increases in ...[more]