Characterization of FLT3-ITDmut acute myeloid leukemia: molecular profiling of leukemic precursor cells.
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ABSTRACT:
SUBMITTER: Travaglini S
PROVIDER: S-EPMC7447750 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Characterization of FLT3-ITD<sup>mut</sup> acute myeloid leukemia: molecular profiling of leukemic precursor cells.
Travaglini Serena S Angelini Daniela Francesca DF Alfonso Valentina V Guerrera Gisella G Lavorgna Serena S Divona Mariadomenica M Nardozza Anna Maria AM Consalvo Maria Irno MI Fabiani Emiliano E De Bardi Marco M Neri Benedetta B Forghieri Fabio F Marchesi Francesco F Paterno Giovangiacinto G Cerretti Raffaella R Barragan Eva E Fiori Valentina V Dominici Sabrina S Del Principe Maria Ilaria MI Venditti Adriano A Battistini Luca L Arcese William W Lo-Coco Francesco F Voso Maria Teresa MT Ottone Tiziana T
Blood cancer journal 20200825 8
Acute myeloid leukemia (AML) with FLT3-ITD mutations (FLT3-ITD<sup>mut</sup>) remains a therapeutic challenge, with a still high relapse rate, despite targeted treatment with tyrosine kinase inhibitors. In this disease, the CD34/CD123/CD25/CD99+ leukemic precursor cells (LPCs) phenotype predicts for FLT3-ITD-positivity. The aim of this study was to characterize the distribution of FLT3-ITD mutation in different progenitor cell subsets to shed light on the subclonal architecture of FLT3-ITD<sup>m ...[more]
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