Ontology highlight
ABSTRACT:
SUBMITTER: Kumondai M
PROVIDER: S-EPMC7447777 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Kumondai Masaki M Hishinuma Eiji E Gutiérrez Rico Evelyn Marie EM Ito Akio A Nakanishi Yuya Y Saigusa Daisuke D Hirasawa Noriyasu N Hiratsuka Masahiro M
Scientific reports 20200825 1
The evaluation of Cytochrome P450 (CYP) enzymatic activity is essential to estimate drug pharmacokinetics. Numerous CYP allelic variants have been identified; the functional characterisation of these variants is required for their application in precision medicine. Results from heterologous expression systems using mammalian cells can be integrated in in vivo studies; however, other systems such as E. coli, bacteria, yeast, and baculoviruses are generally used owing to the difficulty in expressi ...[more]