Ontology highlight
ABSTRACT:
SUBMITTER: Vanachayangkul P
PROVIDER: S-EPMC7449176 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Vanachayangkul Pattaraporn P Im-Erbsin Rawiwan R Tungtaeng Anchalee A Kodchakorn Chanikarn C Roth Alison A Adams John J Chaisatit Chaiyaporn C Saingam Piyaporn P Sciotti Richard J RJ Reichard Gregory A GA Nolan Christina K CK Pybus Brandon S BS Black Chad C CC Lugo-Roman Luis A LA Wegner Matthew D MD Smith Philip L PL Wojnarski Mariusz M Vesely Brian A BA Kobylinski Kevin C KC
Antimicrobial agents and chemotherapy 20200820 9
Previously, ivermectin (1 to 10 mg/kg of body weight) was shown to inhibit the liver-stage development of <i>Plasmodium berghei</i> in orally dosed mice. Here, ivermectin showed inhibition of the <i>in vitro</i> development of <i>Plasmodium cynomolgi</i> schizonts (50% inhibitory concentration [IC<sub>50</sub>], 10.42 μM) and hypnozoites (IC<sub>50</sub>, 29.24 μM) in primary macaque hepatocytes when administered as a high dose prophylactically but not when administered in radical cure mode. The ...[more]