Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka Y
PROVIDER: S-EPMC7449682 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Tanaka Yoshiki Y Yoshikaie Kunihito K Takeuchi Azusa A Ichikawa Muneyoshi M Mori Tomoyuki T Uchino Sayaka S Sugano Yasunori Y Hakoshima Toshio T Takagi Hiroshi H Nonaka Gen G Tsukazaki Tomoya T
Science advances 20200826 35
We have demonstrated that a bacterial membrane protein, YeeE, mediates thiosulfate uptake. Thiosulfate is used for cysteine synthesis in bacteria as an inorganic sulfur source in the global biological sulfur cycle. The crystal structure of YeeE at 2.5-Å resolution reveals an unprecedented hourglass-like architecture with thiosulfate in the positively charged outer concave side. YeeE is composed of loops and 13 helices including 9 transmembrane α helices, most of which show an intramolecular pseu ...[more]