Ontology highlight
ABSTRACT:
SUBMITTER: Guo WH
PROVIDER: S-EPMC7450057 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Nature communications 20200826 1
Current efforts in the proteolysis targeting chimera (PROTAC) field mostly focus on choosing an appropriate E3 ligase for the target protein, improving the binding affinities towards the target protein and the E3 ligase, and optimizing the PROTAC linker. However, due to the large molecular weights of PROTACs, their cellular uptake remains an issue. Through comparing how different warhead chemistry, reversible noncovalent (RNC), reversible covalent (RC), and irreversible covalent (IRC) binders, a ...[more]