Ontology highlight
ABSTRACT:
SUBMITTER: Battey E
PROVIDER: S-EPMC7450176 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Battey Edmund E Stroud Matthew J MJ Ochala Julien J
Clinical science (London, England : 1979) 20200801 16
Skeletal muscle weakness is an important determinant of age-related declines in independence and quality of life but its causes remain unclear. Accelerated ageing syndromes such as Hutchinson-Gilford Progerin Syndrome, caused by mutations in genes encoding nuclear envelope proteins, have been extensively studied to aid our understanding of the normal biological ageing process. Like several other pathologies associated with genetic defects to nuclear envelope proteins including Emery-Dreifuss mus ...[more]