Dataset Information

Obtaining and Investigation of the ?-Cyclodextrin Inclusion Complex with Vitamin D 3 Oil Solution.

ABSTRACT: Background. The research results of fat-soluble vitamin D 3 (cholecalciferol) encapsulation with ?-cyclodextrin have been presented in this work. The vitamin D 3 inclusion complex with ?-cyclodextrin was obtained under microwave radiation. The surface morphology of obtained clathrate inclusion complexes was described with the help of a scanning electron microscope. The thermographic measurement results on a differential scanning calorimeter have been presented. The activation energy of the ?-cyclodextrin?:?vitamin D 3 clathrate complex thermal oxidative destruction reaction was calculated. The clathrate thermal destruction kinetic parameters were determined. The inclusion complex spectral properties were characterized by IR-Fourier and 1H and 13C NMR spectroscopy. The existence of ?-cyclodextrin inclusion complex with vitamin D 3 in a 2?:?1 ratio was confirmed by the experimental results. The activation energy of thermal destruction of the inclusion complex of ?-cyclodextrin with vitamin D 3 was calculated using four different methods.

SUBMITTER: Bakirova R

PROVIDER: S-EPMC7450341 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Obtaining and Investigation of the β-Cyclodextrin Inclusion Complex with Vitamin D 3 Oil Solution.

Bakirova Ryszhan R Nukhuly Altynbek A Iskineyeva Ainara A Fazylov Serik S Burkeyev Meiram M Mustafayeva Ayaulym A Minayeva Yelena Y Sarsenbekova Akmaral A

Scientifica 20200817

Background. The research results of fat-soluble vitamin D 3 (cholecalciferol) encapsulation with β-cyclodextrin have been presented in this work. The vitamin D 3 inclusion complex with β-cyclodextrin was obtained under microwave radiation. The surface morphology of obtained clathrate inclusion complexes was described with the help of a scanning electron microscope. The thermographic measurement results on a differential scanning calorimete ...[more]

PMID: 32908782

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Project description:Piroxicam (Px) is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of osteoarthritis and rheumatoid arthritis. It is administered orally; however, its poor water solubility causes low loading to the nonconventional drug delivery systems (DDSs), such as electrospun fibers. Furthermore, the rapid dissolution of DDS and fast release of the embedded drugs are crucial for oral delivery of drugs to patients who are unconscious or suffering from dysphagia. In this regard, this study reports the development of rapidly dissolving cyclodextrin (CD)-based inclusion complex (IC) nanofibers by waterborne electrospinning for fast oral delivery of Px. Scanning electron microscopy analysis revealed the formation of bead-free fibers with a mean diameter range of 170-500 nm at various concentrations of Px; increasing the Px loading decreased the fiber diameter. The formation of IC was demonstrated by X-ray diffraction (XRD) analysis by the disappearance of crystalline peaks of Px. Likewise, differential scanning calorimetry (DSC) analysis showed the disappearance of the melting peak of the embedded Px due to IC formation. Both Fourier transform infrared (FTIR) and thermogravimetric analysis (TGA) confirmed the presence of Px within the fibers. 1H NMR experiments demonstrated Px preservation in the fibers after six months. Px-loaded nanofibers were employed for sublingual drug delivery. To mimic the environment of the mouth, the nanofibers were treated with artificial saliva, which revealed the instant dissolution of the nanofibers. Furthermore, dissolution experiments were performed on the tissues wetted with artificial saliva, where the dissolution of the fibers could be extended to a few seconds, demonstrating the suitability of the materials for sublingual oral drug delivery. Overall, this paper, for the first time, reports the rapid oral delivery of Px from polymer-free CD fibers produced by waterborne electrospinning without the requirement of any carrier polymer and toxic solvent.

Dataset Information

Obtaining and Investigation of the ?-Cyclodextrin Inclusion Complex with Vitamin D 3 Oil Solution.

Publications

Obtaining and Investigation of the <i>β</i>-Cyclodextrin Inclusion Complex with Vitamin <i>D</i> <sub>3</sub> Oil Solution.

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