Obtaining and Investigation of the ?-Cyclodextrin Inclusion Complex with Vitamin D 3 Oil Solution.

ABSTRACT: Background. The research results of fat-soluble vitamin D 3 (cholecalciferol) encapsulation with ?-cyclodextrin have been presented in this work. The vitamin D 3 inclusion complex with ?-cyclodextrin was obtained under microwave radiation. The surface morphology of obtained clathrate inclusion complexes was described with the help of a scanning electron microscope. The thermographic measurement results on a differential scanning calorimeter have been presented. The activation energy of the ?-cyclodextrin?:?vitamin D 3 clathrate complex thermal oxidative destruction reaction was calculated. The clathrate thermal destruction kinetic parameters were determined. The inclusion complex spectral properties were characterized by IR-Fourier and 1H and 13C NMR spectroscopy. The existence of ?-cyclodextrin inclusion complex with vitamin D 3 in a 2?:?1 ratio was confirmed by the experimental results. The activation energy of thermal destruction of the inclusion complex of ?-cyclodextrin with vitamin D 3 was calculated using four different methods.

SUBMITTER: Bakirova R 

PROVIDER: S-EPMC7450341 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature