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Objective outcome measures: Collecting meaningful data on alopecia areata.

ABSTRACT: BACKGROUND:Although alopecia areata is a common disorder, it has no US Food and Drug Administration-approved treatment and evidence-based therapeutic data are lacking. OBJECTIVE:To develop guidelines for the diagnosis, evaluation, assessment, response criteria, and end points for alopecia areata. METHODS:Literature review and expert opinion of a group of dermatologists specializing in hair disorders. RESULTS:Standardized methods of assessing and tracking hair loss and growth, including new scoring techniques, response criteria, and end points in alopecia areata are presented. LIMITATIONS:The additional time to perform the assessments is the primary limitation to use of the methodology in clinical practice. CONCLUSION:Use of these measures will facilitate collection of standardized outcome data on therapeutic agents used in alopecia areata both in clinical practice and in clinical trials.

SUBMITTER: Olsen EA

PROVIDER: S-EPMC7450487 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Objective outcome measures: Collecting meaningful data on alopecia areata.

Olsen Elise A EA Roberts Janet J Sperling Leonard L Tosti Antonella A Shapiro Jerry J McMichael Amy A Bergfeld Wilma W Callender Valerie V Mirmirani Paradi P Washenik Ken K Whiting David D Cotsarelis George G Hordinsky Maria M

Journal of the American Academy of Dermatology 20171108 3

<h4>Background</h4>Although alopecia areata is a common disorder, it has no US Food and Drug Administration-approved treatment and evidence-based therapeutic data are lacking.<h4>Objective</h4>To develop guidelines for the diagnosis, evaluation, assessment, response criteria, and end points for alopecia areata.<h4>Methods</h4>Literature review and expert opinion of a group of dermatologists specializing in hair disorders.<h4>Results</h4>Standardized methods of assessing and tracking hair loss an ...[more]

PMID: 29128463

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Project description:IntroductionIndividuals with alopecia areata (AA) may experience significant impacts on their health-related quality of life. The novel Alopecia Areata Patient Priority Outcomes (AAPPO) questionnaire has been developed to assess hair loss signs, emotional symptoms, and activity limitations associated with AA. The objective of this study was to evaluate psychometric properties and establish scoring of the AAPPO in adults and adolescents with AA.MethodsScoring and measurement properties of the AAPPO were examined using baseline and 2-week follow-up data from a prospective, noninterventional, web-based study of 121 patients with AA (85 adults aged ≥ 18 years, 36 adolescents aged 12-17 years) with Severity of Alopecia Tool (SALT) ≥ 25% scalp hair loss.ResultsExploratory and confirmatory factor analysis supported four single Hair Loss (HL) items, an Emotional Symptoms domain (ES; 4 items), and an Activity Limitations domain (AL; 3 items). Among all patients, the multi-item ES and AL domains had strong internal consistency (α ≥ 0.87); all HL items and domain scores had strong test-retest reliability (weighted kappa or intraclass correlation coefficients ≥ 0.78). All HL item scores demonstrated strong construct validity (r ≥ 0.52) compared with the patient-reported Alopecia Areata Symptom and Impact Scale (AASIS) hair loss subscale score; ES and AL domain scores exhibited strong construct validity (r ≥ 0.66) compared with the SF-36 Mental Component Summary (MCS) score. Using SALT scores, HL mean item scores were better (lower) in the 25-49% SALT subgroup versus those with highest SALT scores (76-100%); however, ES mean domain scores were better in the SALT 76-100% subgroup in the same comparison (p < 0.0001). Using AASIS and MCS score-created subgroups, ES and AL mean domain scores demonstrated hypothesized differences across subgroups (all p values < 0.0001).ConclusionThe AAPPO questionnaire is a reliable, valid disease-specific measure of hair loss severity and impact in individuals with AA.

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Objective outcome measures: Collecting meaningful data on alopecia areata.

Publications

Objective outcome measures: Collecting meaningful data on alopecia areata.

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