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The involvement of exosomes in the diagnosis and treatment of pancreatic cancer.


ABSTRACT: At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominent mediator of intercellular communication, and they regulate, instruct, and re-educate their surrounding microenvironment and target specific organs. Due to accumulative evidence proved that exosomes are involved in metastasis, cell proliferation, EMT, angiogenesis, and TME of pancreatic cancer, exosomes are crucial potential candidates to detect pancreatic cancer early. This review aims to convey the current understanding of the main functions employed by exosomes in early diagnosis and treatment of pancreatic cancer.

SUBMITTER: Ariston Gabriel AN 

PROVIDER: S-EPMC7450552 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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The involvement of exosomes in the diagnosis and treatment of pancreatic cancer.

Ariston Gabriel Abakundana Nsenga AN   Wang Fang F   Jiao Qinlian Q   Yvette Umwali U   Yang Xuemei X   Al-Ameri Samed Ahmed SA   Du Lutao L   Wang Yun-Shan YS   Wang Chuanxin C  

Molecular cancer 20200827 1


At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominent mediator of intercellular communication, and they regulate, instruct, and re-educate their surrounding microenvironment and target specific organs. Due to accumulative evidence pr  ...[more]

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