Unknown

Dataset Information

0

An unexpected effect of acetal stereochemistry on the course of its reductive cleavage.


ABSTRACT: Alternate routes to the BC spirocycle of 'upenamide starting from Diels-Alder adduct 1 are described. Key to utilizing 1 in a synthesis of 'upenamide is the differentiation of three functionalized carbons by either oxidation or protection state. A surprising effect of acetal stereochemistry on reaction course was observed and rationalized.

SUBMITTER: Wenzler ME 

PROVIDER: S-EPMC7451082 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

An unexpected effect of acetal stereochemistry on the course of its reductive cleavage.

Wenzler Marta E ME   Sulikowski Gary A GA  

Tetrahedron letters 20160616 30


Alternate routes to the BC spirocycle of 'upenamide starting from Diels-Alder adduct <b>1</b> are described. Key to utilizing <b>1</b> in a synthesis of 'upenamide is the differentiation of three functionalized carbons by either oxidation or protection state. A surprising effect of acetal stereochemistry on reaction course was observed and rationalized. ...[more]

Similar Datasets

| S-EPMC9011353 | biostudies-literature
| S-EPMC4599693 | biostudies-literature
| S-EPMC5103641 | biostudies-literature
| S-EPMC6644787 | biostudies-literature
| S-EPMC6001451 | biostudies-literature
| S-EPMC1851890 | biostudies-other
| S-EPMC2736464 | biostudies-literature
| S-EPMC3726663 | biostudies-literature
| S-EPMC2817006 | biostudies-literature
| S-EPMC5501486 | biostudies-literature