Primate differential redoxome (PDR) - A paradigm for understanding neurodegenerative diseases.
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ABSTRACT:
SUBMITTER: Venkatachalam N
PROVIDER: S-EPMC7451816 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Primate differential redoxome (PDR) - A paradigm for understanding neurodegenerative diseases.
Venkatachalam Nachiyappan N Bakavayev Shamchal S Engel Daniel D Barak Zeev Z Engel Stanislav S
Redox biology 20200812
Despite different phenotypic manifestations, mounting evidence points to similarities in the molecular basis of major neurodegenerative diseases (ND). CNS has evolved to be robust against hazard of ROS, a common perturbation aerobic organisms are confronted with. The trade-off of robustness is system's fragility against rare and unexpected perturbations. Identifying the points of CNS fragility is key for understanding etiology of ND. We postulated that the 'primate differential redoxome' (PDR), ...[more]
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