Ontology highlight
ABSTRACT:
SUBMITTER: Frasca A
PROVIDER: S-EPMC7452200 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
JACC. Basic to translational science 20200805 8
Valvular heart diseases are associated with significant cardiovascular morbidity and mortality, and often require surgical and/or percutaneous repair or replacement. Valve replacement is limited to mechanical and biological prostheses, the latter of which circumvent the need for lifelong anticoagulation but are subject to structural valve degeneration (SVD) and failure. Although calcification is heavily studied, noncalcific SVD, which represent roughly 30% of BHV failures, is relatively underinv ...[more]