Engineering Plant Synthetic Pathways for the Biosynthesis of Novel Antifungals.
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ABSTRACT:
SUBMITTER: Calgaro-Kozina A
PROVIDER: S-EPMC7453567 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Engineering Plant Synthetic Pathways for the Biosynthesis of Novel Antifungals.
Calgaro-Kozina Amy A Vuu Khanh M KM Keasling Jay D JD Loqué Dominique D Sattely Elizabeth S ES Shih Patrick M PM
ACS central science 20200720 8
Plants produce a wealth of biologically active compounds, many of which are used to defend themselves from various pests and pathogens. We explore the possibility of expanding upon the natural chemical diversity of plants and create molecules that have enhanced properties, by engineering metabolic pathways new to nature. We rationally broaden the set of primary metabolites that can be utilized by the core biosynthetic pathway of the natural biopesticide, brassinin, producing <i>in planta</i> a n ...[more]
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