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Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder.


ABSTRACT: Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated cortical thickness in individuals with autism spectrum disorder with pharmacological-treatment-refractory aggressive behaviour compared with those with non-refractory aggressive behaviour and observed a brain-wide pattern of local increased thickness in key areas related to emotional control and overall decreased cortical thickness in those with refractory aggressive behaviour, suggesting refractoriness could be related to specific morphological patterns. Elucidating the neurobiology of refractory aggressive behaviour is crucial to provide insights and potential avenues for new interventions.

SUBMITTER: Gouveia FV 

PROVIDER: S-EPMC7453794 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder.

Gouveia Flavia Venetucci FV   Germann Jürgen J   Devenyi Gabriel A GA   Morais Rosa M C B RMCB   Santos Ana Paula M APM   Fonoff Erich T ET   Hamani Clement C   Brentani Helena H   Chakravarty M Mallar MM   Martinez Raquel C R RCR  

BJPsych open 20200807 5


Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated cortical thickness in individuals with autism spectrum disorder with pharmacological-treatment-refractory aggressive behaviour compared with those with non-refractory aggressive behaviour and observed a brain-wide pattern of local increased thicknes  ...[more]

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