Ontology highlight
ABSTRACT:
SUBMITTER: Soulet F
PROVIDER: S-EPMC7453911 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Soulet Fabienne F Bodineau Clement C Hooks Katarzyna B KB Descarpentrie Jean J Alves Isabel I Dubreuil Marielle M Mouchard Amandine A Eugenie Malaurie M Hoepffner Jean-Luc JL López Jose J JJ Rosado Juan A JA Soubeyran Isabelle I Tomé Mercedes M Durán Raúl V RV Nikolski Macha M Villoutreix Bruno O BO Evrard Serge S Siegfried Geraldine G Khatib Abdel-Majid AM
JCI insight 20200723 14
Apelin is a well-established mediator of survival and mitogenic signaling through the apelin receptor (Aplnr) and has been implicated in various cancers; however, little is known regarding Elabela (ELA/APELA) signaling, also mediated by Aplnr, and its role and the role of the conversion of its precursor proELA into mature ELA in cancer are unknown. Here, we identified a function of mTORC1 signaling as an essential mediator of ELA that repressed kidney tumor cell growth, migration, and survival. ...[more]