Ontology highlight
ABSTRACT:
SUBMITTER: van der Wildt B
PROVIDER: S-EPMC7454003 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
van der Wildt Berend B Shen Bin B Chin Frederick T FT
Chemical communications (Cambridge, England) 20190301 21
Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [11C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research. ...[more]