Ontology highlight
ABSTRACT:
SUBMITTER: Shah HB
PROVIDER: S-EPMC7455132 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
JCI insight 20200820 16
Clostridioides difficile is a leading cause of nosocomial infection responsible for significant morbidity and mortality with limited options for therapy. Secreted C. difficile toxin B (TcdB) is a major contributor to disease pathology, and select TcdB-specific Abs may protect against disease recurrence. However, the high frequency of recurrence suggests that the memory B cell response, essential for new Ab production following C. difficile reexposure, is insufficient. We therefore isolated TcdB- ...[more]