Kynurenines link chronic inflammation to functional decline and physical frailty.
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ABSTRACT:
SUBMITTER: Westbrook R
PROVIDER: S-EPMC7455140 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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Kynurenines link chronic inflammation to functional decline and physical frailty.
Westbrook Reyhan R Chung Tae T Lovett Jacqueline J Ward Chris C Joca Humberto H Yang Huanle H Khadeer Mohammed M Tian Jing J Xue Qian-Li QL Le Anne A Ferrucci Luigi L Moaddel Ruin R de Cabo Rafa R Hoke Ahmet A Walston Jeremy J Abadir Peter M PM
JCI insight 20200820 16
Chronic inflammation is associated with physical frailty and functional decline in older adults; however, the molecular mechanisms of this linkage are not understood. A mouse model of chronic inflammation showed reduced motor function and partial denervation at the neuromuscular junction. Metabolomic profiling of these mice and further validation in frail human subjects showed significant dysregulation in the tryptophan degradation pathway, including decreased tryptophan and serotonin, and incre ...[more]
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