Ontology highlight
ABSTRACT:
SUBMITTER: Mostafa D
PROVIDER: S-EPMC7455721 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Communications biology 20200828 1
Pancreatic β-cells are responsible for production and secretion of insulin in response to increasing blood glucose levels. Defects in β-cell function lead to hyperglycemia and diabetes mellitus. Here, we show that CNOT3, a CCR4-NOT deadenylase complex subunit, is dysregulated in islets in diabetic db/db mice, and that it is essential for murine β cell maturation and identity. Mice with β cell-specific Cnot3 deletion (Cnot3βKO) exhibit impaired glucose tolerance, decreased β cell mass, and they g ...[more]