Ontology highlight
ABSTRACT:
SUBMITTER: Xiao S
PROVIDER: S-EPMC7456223 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Xiao Shaohua S Shimura Daisuke D Baum Rachel R Hernandez Diana M DM Agvanian Sosse S Nagaoka Yoshiko Y Katsumata Makoto M Lampe Paul D PD Kleber Andre G AG Hong TingTing T Shaw Robin M RM
The Journal of clinical investigation 20200901 9
Connexin-43 (Cx43) gap junctions provide intercellular coupling, which ensures rapid action potential propagation and synchronized heart contraction. Alterations in Cx43 localization and reductions in gap junction coupling occur in failing hearts, contributing to ventricular arrhythmias and sudden cardiac death. Recent reports have found that an internally translated Cx43 isoform, GJA1-20k, is an auxiliary subunit for the trafficking of Cx43 in heterologous expression systems. Here, we have crea ...[more]