Ontology highlight
ABSTRACT:
SUBMITTER: Andreev D
PROVIDER: S-EPMC7456234 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Andreev Darja D Liu Mengdan M Weidner Daniela D Kachler Katerina K Faas Maria M Grüneboom Anika A Schlötzer-Schrehardt Ursula U Muñoz Luis E LE Steffen Ulrike U Grötsch Bettina B Killy Barbara B Krönke Gerhard G Luebke Andreas M AM Niemeier Andreas A Wehrhan Falk F Lang Roland R Schett Georg G Bozec Aline A
The Journal of clinical investigation 20200901 9
Although the control of bone-resorbing osteoclasts through osteocyte-derived RANKL is well defined, little is known about the regulation of osteoclasts by osteocyte death. Indeed, several skeletal diseases, such as bone fracture, osteonecrosis, and inflammation are characterized by excessive osteocyte death. Herein we show that osteoclasts sense damage-associated molecular patterns (DAMPs) released by necrotic osteocytes via macrophage-inducible C-type lectin (Mincle), which induced their differ ...[more]