A Cell-Based Method to Detect Agonist and Antagonist Activities of Endocrine-Disrupting Chemicals on GPER.
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ABSTRACT:
SUBMITTER: Perian S
PROVIDER: S-EPMC7456940 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
A Cell-Based Method to Detect Agonist and Antagonist Activities of Endocrine-Disrupting Chemicals on GPER.
Périan Séverine S Cerutti Catherine C Forcet Christelle C Tribollet Violaine V Vanacker Jean-Marc JM
Frontiers in endocrinology 20200814
Endocrine-disrupting chemicals (EDCs) are exogenous compounds that impact endogenous hormonal systems, resulting in adverse health effects. These chemicals can exert their actions by interfering with several pathways. Simple biological systems to determine whether EDCs act positively or negatively on a given receptor are often lacking. Here we describe a low-to-middle throughput method to screen the agonist/antagonist potential of EDCs specifically on the GPER membrane estrogen receptor. Applica ...[more]
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