Ontology highlight
ABSTRACT:
SUBMITTER: Canale V
PROVIDER: S-EPMC7458427 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20200811 16
A mechanochemical procedure was developed to obtain <b>PZ-1361</b>, a potent and selective 5-HT<sub>7</sub> receptor antagonist, with antidepressant properties in rodents. The elaborated protocol offered several advantages over classical batch synthesis, including improvement of the overall yield (from 34% to 64%), reduction of reaction time (from 60 to 5.5 h), limitation of the use of toxic solvents, and the formation of byproducts. This approach represents a rare example of the synthesis of bi ...[more]