Ontology highlight
ABSTRACT:
SUBMITTER: Oberman K
PROVIDER: S-EPMC7458552 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Oberman Klaske K Gouweleeuw Leonie L Hoogerhout Peter P Eisel Ulrich L M ULM van Riet Elly E Schoemaker Regien G RG
Journal of Alzheimer's disease reports 20200723 1
<h4>Background</h4>Soluble oligomeric amyloid-β (Aβ), rather than Aβ plaques, seems to be the culprit in Alzheimer's disease (AD). Accordingly, a new concept vaccine of small cyclic peptide conjugates, selectively targeting oligomeric Aβ, has been developed.<h4>Objective</h4>Study the therapeutic potential of this new vaccine in a mouse model for AD.<h4>Methods</h4>J20 mice, overexpressing human amyloid precursor protein, were validated for an AD-like phenotype. Then, J20 mice were vaccinated at ...[more]